Scientist I – Biosystems


Full time

Framingham, MA

Reporting to the Principal Scientist, this Scientist – Oncology is a highly motivated and innovative scientist who is a member of the oncology biology team. This individual develops and implements scientific research in the laboratory as well as collaborates with cross-functional groups to support target validation and drug discovery activities.

Responsibilities

  • Independently develop proposals and implement assays for assessment of potency, target engagement, and mechanism of action of novel compounds using multiple techniques (e.g., recombinant DNA techniques, RNA purification, Western, PCR, RT-qPCR, protein extraction/purification, IP, flow cytometry, plate-based endpoints)
  • Maintain laboratory records and notebook, organize and compile data, and write and present comprehensive reports on results
  • Facilitate interactions with external partners/CROs relevant to experimental projects
  • Handle laboratory workflows, coordinate activities of other personnel, and participate in project/timeline management
  • Mentor and assist junior team members
  • Other duties as assigned

Qualifications

  • Requires a Ph.D. in Molecular Biology, Cell Biology, Biochemistry, or a related field with 0-2 years of related experience
  • Demonstrated proficiency in the assessment of target engagement, identification, and validation of early efficacy biomarkers, in vitro pharmacology, and mechanism of action studies
  • Laboratory skills in mammalian cell culture and molecular techniques are essential; experience in cell-based assay development is preferred
  • Excellent communication and interpersonal skills
  • Able to work in a collaborative, team-oriented environment and demonstrate attention to detail and record-keeping
  • Knowledge of Microsoft Word, GraphPad Prism, and PowerPoint is needed for the preparation of reports to management.

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