Scientist I – Oncology – R & D


Full time

Framingham, MA

The Scientist – Oncology is a highly motivated and innovative scientist who is part of the oncology discovery & development team. The individual in this role works with a cross-functional team and collaborates with cross-functional groups involved in target validation and associated drug discovery & development activities. This individual is responsible for developing and optimizing various assays to investigate the mechanism of action of lead compounds. This role reports to the Associate Director, Oncology.

Responsibilities

  • Independently develop proposals and implement assays for assessment of potency, target engagement, and mechanism of action of novel compounds using multiple techniques (e.g., MSD, Western, flow cytometry, plate-based endpoints) to support company’s “go/no-go” decision.
  • Maintain laboratory records and notebook, organize and compile data, and write and present comprehensive reports on results
  • Facilitate interactions with external partners/CROs relevant to experimental projects
  • Handle laboratory workflows, coordinate activities of other personnel, and participate in project/timeline management
  • Mentor and assist junior team members
  • Other duties as assigned

Qualifications

  • Requires a Ph.D. in cancer biology, biochemistry, or a related field with 0-2 years of related experience or MS with 8+ years of experience in an industry setting
  • Demonstrated proficiency in the assessment of target engagement, identification & validation of early efficacy biomarkers, in vitro pharmacology, and mechanism of action studies
  • Laboratory skills in mammalian cell culture and common molecular techniques are essential; experience in cell-based assay development is preferred
  • Excellent communication and interpersonal skills
  • Able to work in a collaborative, team-oriented environment and demonstrate attention to detail and record-keeping
  • Knowledge of Microsoft Word, GraphPad Prism, and PowerPoint is needed for the preparation of reports to management.