Publications

December 22, 2017

A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells

BMC Genomics. 2017 Dec 22; 18 (1), 987 Jialiang Yang, Jacob Hagen, Kalyani V. Guntur, Kimaada Allette, Sarah Schuyler, Jyoti Ranjan, Francesca Petralia, Stephane Gesta, Robert Sebra, Milind Mahajan, Bin Zhang, Jun Zhu, Sander Houten, Andrew...

October 11, 2017

Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species

WILEY AOCS (2017)  Authors: Fei Gao · Justice McDaniel · Emily Y. Chen · Hannah E. Rockwell · Cindy Nguyen · Matthew D. Lynes · Yu-Hua Tseng · Rangaprasad Sarangarajan · Niven R. Narain · Michael...

August 1, 2017

Reduced Expression of Collagen VI Alpha 3 (COL6A3) Confers Resistance to Inflammation-Induced MCP1 Expression in Adipocytes

Obesity, 2016, Gesta et al Reduction of COL6A3, a novel target discovered by Berg’s Interrogative Biology platform, protects against inflammation associated with obesity Authors: Gesta S, Guntur K, Majumdar ID, Akella S, Vishnudas VK, Sarangarajan R,...

July 21, 2017

Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips

Metabolites, 2017 7(3), 35. BERG developed dried blood spot and dried urine strip workflow using metabolomics platform for potential precision medicine and population health applications. Authors: Jeremy Drolet, Vladimir Tolstikov, Brian Williams, Bennett Greenwood, Collin Hill,...

July 15, 2017

Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips

Metabolites. 2017 Jul 15;7(3) Jeremy Drolet, Vladimir Tolstikov, Brian A. Williams, Bennett P. Greenwood, Collin Hill, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish Analysis of a patient and population’s metabolic profile is...

July 1, 2017

CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density

Biochimica et Biophysica Acta – Biomembranes. 2017 Jul;1859(7):1173-1179 Sumit Garg, Vandana Swaminathan, Sirisha Dhavala, Michael A. Kiebish, Rangaprasad Sarangarajan, Niven R. Narain We investigated the properties of our clinical compound, BPM31510 to determine if the components...

May 1, 2017

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

Nature Medicine. 2017 May;23(5):631-637 Matthew D Lynes, Luiz O Leiria, Morten Lundh, Alexander Bartelt, Farnaz Shamsi, Tian Lian Huang, Hirokazu Takahashi, Michael F Hirshman, Christian Schlein, Alexandra Lee, Lisa A Baer, Francis J May, Fei Gao,...

May 1, 2017

Clinical Metabolomics: A Pivotal Tool for Companion Diagnostic Development and Precision Medicine

Expert Review of Molecular Diagnostics. 2017 May;17(5):411-413 Vladimir Tolstikov, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish Companion diagnostics are useful in determining a positive or negative response to a particular treatment. Clinical...

April 13, 2017

Blood sampled through dried blood spots (DBS) exhibits diminished ex vivo metabolism compared to whole blood through use of a kinetic isotope-labeling metabolomics approach

Biochemistry and Analytical Biochemistry, 2017, 6:2. BERG researchers investigate alternative methods for assessing metabolism in biofluids using an isotope labeling metabolomics approach through dried blood spot analysis. Authors: Collin Hill, Jeremy Drolet, Mark Kellogg, Vladimir Tolstikov,...

April 13, 2017

Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer

Journal of Molecular Biomarkers and Diagnosis, 2017, 8:2, 323. Ravipaty, et al. BERG, LLC, collaborated with Mount Sinai Hospital Toronto to develop and test a novel serum protein panel of three prostate cancer biomarkers for use...

April 13, 2017

CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density

Biochimica et Biophysica Acta, 2017. Garg, et al. BERG, LLC, investigated the biophysical properties of BPM31510, a compound currently in clinical trials for cancer, and demonstrated that the selective incorporation of BPM31510 into cancer cells is...

April 10, 2017

Dynamic and temporal assessment of human dried blood spot MS/MS shotgun lipidomics analysis

Nutrition and Metabolism, 2017, 14: 28. Gao, et al. BERG, LLC, develops a novel mass spectrometry-based method to analyze lipid species from dried blood spot cards which can be used for precision medicine applications and in...

April 10, 2017

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017, Dowal, et al. BERG, LLC, demonstrates that white adipose tissue and macrophages are connected to the induction of low-grade inflammation, whereas brown adipose tissue and macrophages are not; introducing the possibility of...

April 10, 2017

Clinical Metabolomics: A Pivotal Tool for Companion Diagnostic Development and Precision Medicine

Expert Reviews of Molecular Diagnostics, Vol 17, 2017, Tolstikov, et al. – Metabolomics is an essential component of a precision medicine-based strategy for diagnostic and disease therapy. Authors: Vladimir Tolstikov, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven...

April 10, 2017

Predicting Prostate Cancer Progression as a Function of ERG Status, Race & Obesity in a Longitudinal Patient Cohort

European Urology Focus 2017, Cullen et al. –BERG, LLC, collaborates with the Walter Reed National Military Medical Center and Center for Prostate Disease Research (CPDR) to investigate a large, racially diverse military population demonstrating that ERG...

March 20, 2017

Dynamic and temporal assessment of human dried blood spot MS/MSAll shotgun lipidomics analysis

Nutrition & Metabolism. 2017 Mar 20;14:28 Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish Analysis of blood samples is...

February 17, 2017

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017, May et al.- BERG collaborates with Joslin Diabetes Center, Boston, to characterize the lipidome of white and brown adipose tissue in response to exercise Francis J. May, Lisa A. Baer, Adam C. Lehnig,...

February 7, 2017

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports. 2017 Feb 7;18(6):1558-1572 Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A. Kiebish, Laurie J....

January 23, 2017

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

Journal of Extracellular Vesicles, 2016, Haraszti et al – BERG collaborates with UMASS School of Medical to characterize the lipidome of exosomes and microvesicles Authors: Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A....

January 23, 2017

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data Authors: Vijetha Vemulapalli, Jiaqi Qu, Jeonifer M. Garren, Leonardo O. Rodrigues, Michael A. Kiebish, Rangaprasad Sarangarajan, Niven R. Narain, Viatcheslav R. Akmaev...

January 23, 2017

Identification and preliminary assessment of FLNA, FLNB, and KRT19 as potential biomarkers for prostate cancer

Future Science Open Access 2016, Narain et al- Berg’s Interrogative Biology platform discovers a novel biomarker panel for prostate cancer detection in blood samples Authors: Niven R Narain, Anne R Diers, Arleide Lee, Socheata Lao, Joyce...