BOSTON, Nov. 7, 2018 /PRNewswire/ — BERG LLC, a Boston-based biopharmaceutical company that merges biology with technology to map the nature of diseases, today announced four abstracts showcasing the value of its Back to Biology™ approach in identifying disease signatures and mechanisms of Parkinson’s disease (PD) and other neurological disorders were presented at the annual meeting of the Society for Neuroscience (SfN) in San Diego, California, Nov. 3-7, 2018.
Cognitive decline and alterations in motor coordination are some of the earliest symptoms detected in patients with mild cognitive impairments or Parkinson’s disease, respectively, and enhanced understanding of molecular pathways surrounding these has the potential to greatly improve translation of preclinical research toward therapeutic and diagnostic development. BERG’s proprietary Interrogative Biology® platform and bAIcis® artificial intelligence (AI) tool utilize multi-omic profiling and represent one of the most robust platforms for the diagnosis, prognosis and understanding of neurological diseases.
Key presentation highlights include:
Pre-clinical data identifying promising molecules and pathways as target candidates for major depressive disorder.
Pre-clinical metabolic signaling data with potential to distinguish between age-related changes in the brain and age-related cognitive decline in Alzheimer’s disease.
In vitro data suggesting mechanistic link between leucine-rich repeat kinase 2 (LRRK2), p53 inducible gene 3 (PIG3) and PD-related neurodegeneration.
Neurometabolomic and phenotype data supportive of PIG3 as a novel therapeutic target in PD-specific pathologies.
“BERG is leading the way in discovering new therapeutic targets to treat Parkinson’s disease and other neurological disorders by identifying critical links in the neurodegeneration process utilizing our Interrogative Biology platform and AI-driven research into the pathology of disease,” said Niven R. Narain, Ph.D., BERG Co-founder, President and Chief Executive Officer. “Our Back to Biology approach has further identified novel profiles driving disease activity – such as LRRK2 mutation and PIG3 expression – that we believe hold great potential for novel treatments for patients suffering from progressive, debilitating neurodegenerative disorders.”
Details of the poster presentations are as follows and are available via the Neuroscience 2018 website:
Title: Multi-omic analyses of brain and serum from chronically stressed mice reveal network disruptions in purine metabolism, fatty acid beta-oxidation, and antioxidant function that can be ameliorated upon antidepressant treatment Session: 315 Program Number: 315.13 / SS9 Date & Time:November 5, 2018, 8:00 a.m. – 9:00 a.m. PT Location: Halls B-H
Title: A longitudinal analysis of hippocampal metabolomic alterations following cognitive decline in aged mice and APP/PS1 Alzheimer’s disease mice Session: 466 Program Number: 466.05 / F8 Date & Time:November 6, 2018, 8:00 a.m. – 9:00 a.m. PT Location: Halls B-H
Title: p53 inducible gene 3 (PIG3) directly modulates apoptotic responses in human neuronal models of Parkinson’s disease in vitro Session: 655 Program Number: 655.23 / Q11 Date & Time:November 7, 2018, 10:00 a.m. – 11:00 a.m. PT Location: Halls B-H
Title: Altered cellular and metabolomic phenotypes observed in LRRK2G2019S patient-specific iPSC-derived neurons are partially rescued in PIG3-deficient cells Session: 655 Program Number: 655.24 / Q12 Date & Time:November 7, 2018, 11:00 a.m. – 12:00 p.m. PT Location: Halls B-H
About Parkinson’s Disease Parkinson’s Disease (PD) is a chronic and progressive neurological disease that is marked by tremors in the resting muscles, rigidity, slowness of movement, impaired balance, in addition to non-motor symptoms such as behavioral changes and cognitive impairment.1 It’s estimated that 930,000 people in the United States will be living with PD by the year 2020, and predicted to rise to 1.2 million by 2030.2 There currently is no cure for the disease, which is the 14thleading cause of death in the United States.3
About BERG BERG LLC is a clinical-stage, artificial intelligence-powered biotech leveraging its proprietary platform, Interrogative Biology®, to map disease and revolutionize treatments across oncology, neurology and rare diseases. By taking a Back to Biology™ approach, BERG is able to identify critical biomarkers that can accelerate the discovery and development of treatments aimed at the most promising therapeutic targets and pathways. BERG has leveraged both Interrogative Biology and traditional R&D methods to develop a robust pipeline of first-in-class product candidates and diagnostics that advance bold innovations that have the potential to improve patient lives. To learn more about how we’re enabling bold innovation, visit berghealth.com.